Process for demineralization of bone matrix with preservation of natural growth factors
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United States of America Patent
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Mar 31, 2015
Grant Date -
Aug 23, 2012
app pub date -
Apr 23, 2012
filing date -
Jun 1, 2007
priority date (Note) -
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Abstract
A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process.
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