Vaccines for malaria

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 8999347
APP PUB NO 20100272788A1
SERIAL NO

12810364

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to a novel lipoprotein particle, methods for preparing and purifying the same, its use in medicine, particularly in the prevention of malarial infections, compositions/vaccines containing the particle or antibodies against the protein particle such as monoclonal or polyclonal antibodies and use of the same, particularly in therapy. Furthermore, particles with the specific ratio can be prepared by employing yeast, Saccharomyces cerevisiae or Pichia pastoris. In particular it relates to an immunogenic protein particle comprising the following monomers:

    a. a fusion protein comprising sequences derived from a CS protein of P. vivax and the S antigen of Hepatitis B (CSV-S), andb. S antigen derived from Hepatitis B virus,and characterized in that the ratio of S to CSV-S is in the range 0.1 to 1. Suitably, the ratio of S to CSV-S is in the range 0.19 to 0.30 or 0.68 to 0.80.

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First Claim

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Patent Owner(s)

  • SMITHKLINE BEECHAM BIOLOGICALS S.A.

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cohen, Joseph D Rixensart, BE 28 563
Marchand, Martine Rixensart, BE 23 77

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