Dual drug dosage forms with improved separation of drugs
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United States of America Patent
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Apr 7, 2015
Grant Date -
Jul 3, 2014
app pub date -
Mar 6, 2014
filing date -
Jul 18, 2003
priority date (Note) -
In Force
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Abstract
Drug tablets that include a prolonged-release core and an immediate-release layer or shell are prepared with a thin barrier layer of drug-free polymer between the prolonged-release and immediate-release portions of the tablet. The barrier layer is penetrable by gastrointestinal fluid, thereby providing full access of the gastrointestinal fluid to the prolonged-release core, but remains intact during the application of the immediate-release layer, substantially reducing or eliminating any penetration of the immediate-release drug into the prolonged-release portion.
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