Discovery and applications of the proteolytic function of N-terminal acetylation of cellular proteins

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United States of America Patent

PATENT NO 8999896
APP PUB NO 20110230370A1
SERIAL NO

13007546

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Abstract

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Screening assays that allow for the identification of agents that modulate the activity of N-terminal acetylation of a polypeptide and the Doa10 branch of the N-end rule pathway are provided. Also provided are methods of using an agent that modulates the activity of N-terminal acetylation of a polypeptide and the Doa10 branch of the N-end rule pathway to increase or decrease protein degradation in a cell, and to modulate physiologic and pathologic associated with N-terminal acetylation of a polypeptide and the Doa10 branch of the N-end rule pathway.

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Patent Owner(s)

Patent OwnerAddress
CALIFORNIA INSTITUTE OF TECHNOLOGY1200 E CALIFORNIA BLVD MC 210-85 PASADENA CA 91125

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hwang, Cheol-Sang Arcadia, US 3 0
Shemorry, Anna Pasadena, US 1 0
Varshavsky, Alexander La Canada, US 46 955

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