Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof

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United States of America Patent

PATENT NO 8999936
APP PUB NO 20130236452A1
SERIAL NO

13780643

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Abstract

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The invention relates to an isolated monoclonal antibody or antigen-binding fragment thereof that (a) binds (i) wild-type Aβ 42/40 protofibril comprising N-terminal truncated Aβ forms and (ii) Aβ 42/40 Arc protofibril comprising N-terminal truncated Aβ forms and (b) has no or little cross-reactivity to Aβ 42/40 monomers. The invention further relates to a method of using such an antibody to treat Alzheimer's disease.

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Patent Owner(s)

Patent OwnerAddress
BIOARCTIC NEUROSCIENCE ABSTOCKHOLM SWE STOCKHOLM

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gellerfors, Pär Lidingö, SE 13 158
Lannfelt, Lars Stockholm, SE 25 433

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