Photocleavable sense-antisense complex

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United States of America Patent

PATENT NO 9000142
APP PUB NO 20100105120A1
SERIAL NO

12489434

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Abstract

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There is disclosed a photocleavable sense-antisense nucleobase polymer complex capable of modulating gene expression comprising an unnatural antisense nucleobase polymer that targets an mRNA, and a photocleavable sense nucleobase polymer noncovalently bound to the antisense nucleobase polymer, wherein the photocleavable sense nucleobase polymer comprises a plurality of nucleobase polymers connected by a photocleavable linkage. There is also disclosed a method for controlling the time and spatial position of gene expression comprising selecting a target mRNA, introducing the photocleavable sense-antisense nucleobase polymer complex into a cell, and selectively irradiating the cell with light.

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Patent OwnerAddress
SYNTRIX BIOSYSTEMS INC215 CLAY STREET NW SUITE B-5 AUBURN WA 98001

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Zebala, John A Sammamish, US 38 403

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