Activated nitric oxide donors and methods of making and using thereof
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United States of America Patent
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Apr 14, 2015
Grant Date -
Jul 28, 2011
app pub date -
Mar 5, 2009
filing date -
Mar 7, 2008
priority date (Note) -
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Abstract
Described herein are compositions useful in anticancer treatment and prevention. The compositions are composed of (a) an O2-aryl substituted diazeniumdiolate and (b) an amphiphile, wherein the amount of amphiphile is sufficient to produce a liposome or micelle. The compositions described herein provide numerous advantages such as increased solubility and stability of the O2-aryl substituted diazeniumdiolate in vivo. The compositions also do not induce hypotension. Methods for using the compositions in anticancer treatment and prevention are also described herein.
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