Compositions for elastogenesis and connective tissue treatment
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United States of America Patent
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Apr 14, 2015
Grant Date -
Sep 30, 2010
app pub date -
Jan 12, 2010
filing date -
Feb 20, 2004
priority date (Note) -
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Abstract
The present invention describes therapeutic compositions comprising one or more minerals, including trivalent iron, divalent manganese and salts thereof, suitable in facilitating synthesis and deposition of connective tissue matrix, particularly rich of elastin and collagen, and mitogenic potential in human dermal fibroblasts. It also describes the phenomenon in which stimulation of elastogenesis by arterial SMC associates with a net decrease in proliferation of these cell types. The present invention also describes methods of treatment of human skin fibroblasts and arterial smooth muscle cells. The therapeutic compositions of the present invention comprise one or more of trivalent iron or divalent manganese or salts thereof and may be combined with an elastic tissue digest.
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