Human binding molecules capable of neutralizing influenza virus H5N1 and uses thereof
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United States of America Patent
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Apr 21, 2015
Grant Date -
Nov 1, 2012
app pub date -
Apr 27, 2012
filing date -
Sep 7, 2006
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Abstract
Described are binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus H5N1. Also described are nucleic acid molecules encoding the antibodies, and compositions comprising the antibodies and methods of identifying or producing the antibodies. The antibodies can be used in the diagnosis, prophylaxis, and/or treatment of an influenza virus H5N1 infection. In certain embodiments, the antibodies provide cross-subtype protection in vivo, such that infections with H5, H2, H6, H9, and H1-based influenza subtypes can be prevented and/or treated.
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