Bifunctional protein anchors

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United States of America Patent

PATENT NO 9011870
SERIAL NO

11989118

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Abstract

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The invention relates to the areas of immunology and vaccine delivery. More specifically, it relates to a bacterial vaccine delivery technology with built-in immunostimulatory properties which allows the immobilization of any antigen of interest, without prior antigen modification. Provided is an antigen-loaded immunogenic carrier complex comprising at least one bifunctional polypeptide attached to an immunogenic carrier, said bifunctional polypeptide comprising a peptidoglycan binding domain (PBD) through which the polypeptide is attached to said carrier, fused to an antigen binding domain (ABD) to which at least one antigen of interest is bound. Also provided is a pharmaceutical (e.g. vaccine) composition comprising an antigen-loaded immunogenic carrier complex of the invention.

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Patent Owner(s)

  • APPLIED NANOSYSTEMS B.V.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bosma, Tjibbe Lippenhuizen, NL 6 12
Leenhouts, Cornelis Johannes Haren, NL 18 104
Van, Roosmalen Maarten Leonardus Groningen, NL 5 13

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