Methods for the acylation of maytansinol

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United States of America Patent

PATENT NO 9012629
SERIAL NO

14037657

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Abstract

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Disclosed is a method of preparing an amino acid ester of maytansinol by reacting maytansinol with an N-carboxyanhydride of an amino acid (NCA) in the presence of a drying agent. Also disclosed is an improved method of preparing an amino acid ester of maytansinol in which a nucleophile is added to the reaction mixture after completion of the reaction between maytansinol and an N-carboxyanhydride of an amino acid.

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Patent Owner(s)

  • IMMUNOGEN, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Widdison, Wayne C Belmont, US 37 927
Zhao, Robert Yongxin Lexington, US 71 1112

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