Treatment method using EGFR antibodies and SRC inhibitors and related formulations

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United States of America Patent

PATENT NO 9023356
APP PUB NO 20100092475A1
SERIAL NO

12450196

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Abstract

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The present invention relates to the treatment of EGFR-mediated disease, particularly cancer by inhibiting or blocking EGFR and src in combination or simultaneously. The invention relates to treatment, prevention, or modulation of cancer, particularly EGFR-mediated disease, with one or more EGFR modulator and src inhibitor in combination. The invention further relates to the treatment of cancer with anti-EGFR antibodies and src inhibitors. Methods and compositions for treatment of cancer with the antibody anti-EGFR mAb806 in combination or series with a src inhibitor or src inhibitors are described.

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Patent Owner(s)

  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cavenee, Webster La Jolla, US 8 42
Furnari, Frank La Jolla, US 7 32
Johns, Terrance Grant Heidelberg, AU 17 195
Scott, Andrew Heidelberg, AU 31 308

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