Method for preparing optically pure (+)-ambrisentan and (+)-darusentan

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United States of America Patent

PATENT NO 9040698
APP PUB NO 20140249309A1
SERIAL NO

14125054

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Abstract

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Disclosed is a method for preparing optically pure (+)-ambrisentan and (+)-darusentan, comprising: firstly catalyzing the asymmetric epoxidation of a β-unsaturated alkene using a chiral ketone derived from fructose or a hydrate thereof as a catalyst, and then subjecting the product to an epoxy compound ring-opening reaction and substitution reaction successively to obtain optically pure (+)-ambrisentan and (+)-darusentan.

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Patent Owner(s)

Patent OwnerAddress
INSTITUTE OF CHEMISTRY CHINESE ACADEMY OF SCIENCES100190 INSTITUTE OF CHEMISTRY CHINESE ACADEMY OF SCIENCES NORTH 1ST STREET ZHONGGUANCUN HAIDIAN DISTRICT BEIJING BEIJING CITY BEIJING CITY 100190

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Li, Peijun Beijing, CN 10 4
Peng, Xianyou Beijing, CN 5 0
Shi, Yian Beijing, CN 9 24

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