Processes and intermediates in the preparation of morphine analogs via N-demethylation of N-oxides using cyclodehydration reagents

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United States of America Patent

PATENT NO 9045497
APP PUB NO 20150133665A1
SERIAL NO

14591382

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A high-yielding method for the N-demethylation of oxycodone- and oxymorphone-N-oxides by the reaction of these compounds with cyclodehydration reagents has been performed. This method has been utilized to improve the synthesis of various morphine analogs, such as naltrexone, nalbuphone and naloxone.

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BROCK UNIVERSITY500 GLENRIDGE AVENUE ST CATHARINES L2S 3A1

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Endoma-Arias, Mary Ann Quezon, PH 7 20
Hudlicky, Tomas Ontario, CA 33 176
Machara, Ales Brevnov, CZ 10 27
Werner, Lukas Kadan, CZ 12 39
Wernerova, Martina Svidnik, SK 2 5

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