Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions

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United States of America Patent

PATENT NO 9045528
SERIAL NO

13151195

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A method of engineering immunoglobulins which each have one or more amino acid modifications in at least one structural loop region of such immunoglobulins, where the modified loop region specifically binds to an epitope of an antigen to which an unmodified immunoglobulin does not significantly bind.

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Patent Owner(s)

Patent OwnerAddress
F-STAR THERAPEUTICS LIMITEDEDDEVA B920 BABRAHAM RESEARCH CAMPUS CAMBRIDGE CB22 3AT

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Himmler, Gottfried Vienna, AT 55 541
Ruker, Florian Vienna, AT 23 365
Wozniak-Knopp, Gordana Vienna, AT 22 218

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