Osmolyte mixture for protein stabilization

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United States of America Patent

PATENT NO 9052323
APP PUB NO 20110053795A1
SERIAL NO

12870236

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Abstract

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An osmolyte composition comprising 4 M glycerol and 4M urea for stabilizing previously transient protein folding intermediates as long-lived stable forms. A method to search for other possible stabilizing osmolyte mixtures using a screening array is also provided. These additional osmolyte mixtures may complement or augment the successful 4M glycerol/4 M urea mixture.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF KANSAS MEDICAL CENTERKANSAS CITY KS

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fisher, Mark T Shawnee Mission, US 11 445
Katayama, Hiroo Kansas City, US 5 64

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