Treating stroke and other diseases without inhibiting N-type calcium channels
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United States of America Patent
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Jun 23, 2015
Grant Date -
Jul 4, 2013
app pub date -
Sep 14, 2012
filing date -
Mar 2, 2007
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Abstract
The invention provides methods for treating stroke and compositions for use in the same. The methods employ a chimeric peptide of an active peptide and an internalization peptide. The internalization peptide is a tat variant that promotes uptake of itself and a linked active peptide into a cell without substantial binding to N-type calcium channels. Use of the tat variant allows treating of stroke free of certain side effects associated with binding to N-type calcium channels. Tat variant peptides can also be linked to other active agent for use in treating other diseases.
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