Methods and kits for volumetric distribution of pharmaceutical agents via the vascular adventitia and microcirculation
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United States of America Patent
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Jun 23, 2015
Grant Date -
Oct 9, 2014
app pub date -
Mar 11, 2014
filing date -
Jan 22, 2002
priority date (Note) -
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Abstract
Methods and kits for delivering pharmaceutical agents to the adventitia and other regions outside the external elastic lamina (EEL) surrounding a blood vessel utilize a catheter having a needle. The needle is positioned in up to 5 mm beyond the EEL and delivers an amount of pharmaceutical agent sufficient to circumferentially permeate around the blood vessel and, in many cases, extend longitudinally and radially along the blood vessel. Confirmation that a delivery aperture of the needle lies beyond the EEL may be required before delivering the pharmaceutical agent.
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