Ruthenium carbon monoxide releasing molecules and uses thereof

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United States of America Patent

PATENT NO 9062089
APP PUB NO 20140219996A1
SERIAL NO

14234024

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Abstract

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The present invention provides novel ruthenium compounds of Formula (I): or salts, isomers, hydrates, or solvates thereof, or combinations thereof; wherein E, R1, R2, R3, R4, R5, X1, and X2 are as defined herein, and pharmaceutical compositions thereof. Also provided are methods of use and treatment. Such compounds have been found useful in the treatment of malaria infection. Such compounds may also be useful in the treatment of inflammatory conditions, such as acute lung injury and acute respiratory distress syndrome, which optionally may be associated with a malaria infection.

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Patent Owner(s)

Patent OwnerAddress
ALFAMA INC955 MASSACHUSETTS AVENUE #581 CAMBRIDGE MA 02139

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bernardes, Gonçalo J L Torres Vedras, PT 2 2
Mota, Maria M Lisbon, PT 5 13
Pamplona, Ana Lisbon, PT 2 4
Romão, Carlos C Cascais, PT 4 7

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