Systems and methods for transcriptome analysis
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United States of America Patent
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Jun 23, 2015
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Jan 17, 2014
filing date -
Oct 21, 2013
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Abstract
The invention generally provides systems and methods for analysis of RNA-Seq reads in which an annotated reference is represented as a directed acyclic graph (DAG) or similar data structure. Features such as exons and introns from the reference provide nodes in the DAG and those features are linked as pairs in their canonical genomic order by edges. The DAG can scale to any size and can in fact be populated in the first instance by import from an extrinsic annotated reference.
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