Process for making sterile aripiprazole of desired mean particle size
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United States of America Patent
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Jun 30, 2015
Grant Date -
Jun 27, 2013
app pub date -
Feb 20, 2013
filing date -
Oct 23, 2003
priority date (Note) -
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Abstract
A process is provided for making sterile aripiprazole having an average particle size less than 100 microns but preferably greater than 25 microns employing an impinging jet crystallization procedure. The resulting bulk aripiprazole of desired particle size may be used to form a sterile freeze-dried aripiprazole formulation, which upon constitution with water and intramuscular injection releases aripiprazole over a period of at least about one week and up to about eight weeks.
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