Micro-RNAs of the miR-15 family modulate cardiomyocyte survival and cardiac repair

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United States of America Patent

PATENT NO 9078919
APP PUB NO 20140051745A1
SERIAL NO

13970379

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Abstract

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A family of microRNAs, called the miR-15 family, which includes miR-195, are shown to be up-regulated during pathological cardiac remodeling and repress the expression of mRNAs required for cell proliferation and survival, with consequent loss of cardiomyocytes. Strategies to block expression of the miR-15 family in the heart as a treatment for diverse cardiac disease are provided.

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Patent Owner(s)

  • BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Olson, Eric N Dallas, US 57 262
van, Rooij Eva Utrecht, NL 31 183

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