Unnatural amino acids comprising a cyclooctynyl or trans-cyclooctenyl analog group and uses thereof

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United States of America Patent

PATENT NO 9085514
APP PUB NO 20140073764A1
SERIAL NO

13982446

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Abstract

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The present invention relates to unnatural amino acids comprising a cyclooctynyl or trans-cyclooctenyl analog group and having formula (I) or an acid or base addition salt thereof. The invention also relates to the use of said unnatural amino acids, kits and processes for preparation of polypeptides that comprise one or more than one cyclooctynyl or trans-cyclooctenyl analog group. These polypeptides can be covalently modified by in vitro or in vivo reaction with compounds comprising an azide, nitrile oxide, nitrone, diazocarbonyl or 1,2,4,5-tetrazine group.

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  • EMBL

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Koehler, Christine Forst, DE 2 6
Lemke, Edward Mannheim, DE 6 10
Milles, Sigrid Mannheim, DE 2 9
Plass, Tilman Heidelberg, DE 3 6
Schultz, Carsten Heidelberg, DE 13 54

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