lipopolysaccharide outer core epitope
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United States of America Patent
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Jul 21, 2015
Grant Date -
Jun 28, 2012
app pub date -
Jul 30, 2010
filing date -
Jul 31, 2009
priority date (Note) -
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Abstract
Helicobacter pylori, one of the most common human pathogens, is associated with the development of human chronic gastritis, peptic ulcers and gastric cancer. The invention relates to a α1,6-glucan-containing Helicobacter pylori compound comprising the structure of Formula (I): wherein R is a α-DDHep-3-α-L-Fuc-3-β-GlcNAc trisaccharide substituted with an α1,6-glucan linked to an α1,3-DD-heptan, and wherein the last DD-Hep residue of α1,3-DD-heptan is capped with β-GlcNAc residue. Compositions comprising the compound, uses of the compound, and antibodies raised against the compound are also described.
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