Antibodies to IL-6 to inhibit or treat inflammation

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United States of America Patent

PATENT NO 9085615
SERIAL NO

13682214

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention is directed to therapeutic methods using IL-6 antagonists such as an Ab1 antibody or antibody fragment having binding specificity for IL-6 to prevent or treat disease or to improve survivability or quality of life of a patient in need thereof. In preferred embodiments these patients will comprise those exhibiting (or at risk of developing) an elevated serum C-reactive protein level, reduced serum albumin level, elevated D-dimer or other coagulation cascade related protein(s), cachexia, fever, weakness and/or fatigue prior to treatment. The subject therapies also may include the administration of other actives such as chemotherapeutics, anti-coagulants, statins, and others.

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Patent Owner(s)

  • ALDERBIO HOLDINGS LLC

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Anderson, Katie Kirkland, US 27 139
Carvalho, Jensen Ann Elisabeth Snohomish, US 3 24
Dutzar, Benjamin H Seattle, US 89 762
Garcia-Martinez, Leon F Woodinville, US 93 892
Kovacevich, Brian R Snohomish, US 39 404
Latham, John A Seattle, US 92 1175
Ojala, Ethan W Snohomish, US 58 412
Smith, Jeffrey T L Bellevue, US 93 1198

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