Process for the preparation of morphine analogs via metal catalyzed N-demethylation/functionalization and intramolecular group transfer

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 9108967
APP PUB NO 20150094471A1
SERIAL NO

14571714

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

The present application is directed to an efficient conversion of C-14 hydroxylated morphine alkaloids to various morphine analogs, such as naltrexone, naloxone and nalbuphone. One feature of this process is an intramolecular functional group transfer from the C-14 hydroxyl to the N-17 nitrogen atom following a palladium-catalyzed N-demethylation.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddress
BROCK UNIVERSITY500 GLENRIDGE AVENUE ST CATHARINES L2S 3A1

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hudlicky, Tomas St. Catharines, CA 33 176
Machara, Ales Brevnov, CZ 10 27

Cited Art Landscape

Load Citation

Patent Citation Ranking

Forward Cite Landscape

Load Citation

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
11.5 Year Payment $7400.00 $3700.00 $1850.00 Feb 18, 2027
Fee Large entity fee small entity fee micro entity fee
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00