Antibody targeting osteoclast-related protein Siglec-15

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United States of America Patent

PATENT NO 9114131
APP PUB NO 20130280276A1
SERIAL NO

13877779

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Abstract

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An isolated antibody capable of binding Siglec-15 which inhibits osteoclast formation and/or osteoclastic bone resorption, or a functional fragment thereof. The heavy chain of the antibody comprises a CDRH1 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 106, a CDRH2 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 107, and a CDRH3 comprising a sequence having at least 80% sequence identity to one of SEQ ID NOS: 35, 45, 55, 65 or 80. The light chain of the antibody comprises a CDRL1 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 73 or 83, a CDRL2 comprising a sequence having at least 80% sequence identity to SEQ ID NO: 108, and a CDRL3 comprising a sequence having at least 80% sequence identity to one of SEQ ID NOS: 40, 50, 60, 70, 90, 100 or 109.

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Patent Owner(s)

  • DAIICHI SANKYO COMPANY, LIMITED

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Agatsuma, Toshinori Tokyo, JP 17 91
Baehs, Kathrin-Ladetzki Martinsried/Planegg, DE 1 10
Hiruma, Yoshiharu Tokyo, JP 15 111
Mühlbacher, Robert Martinsried/Planegg, DE 3 10
Matsuoka, Tatsuji Tokyo, JP 10 79
Miller, Sandra Munich, DE 12 22
Ohtsuka, Toshiaki Tokyo, JP 15 58
Ponsel, Dirk Germering, DE 5 12
Runz, Steffen Martinsried/Planegg, DE 8 10
Schubert, Ulrike Munich, DE 5 37
Schuster, Ingrid Munich, DE 9 41
Takahashi, Tohru Tokyo, JP 98 1523
Tsuda, Eisuke Tokyo, JP 40 326
Watanabe, Ichiro Tokyo, JP 49 578

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