Immunoconjugate formulations

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United States of America Patent

PATENT NO 9114179
APP PUB NO 20070031402A1
SERIAL NO

11498139

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Abstract

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The present invention provides an immunoconjugate formulation that is substantially free of particles, the immunoconjugate formulation comprising: an immunoconjugate and one or more excipients selected from the group consisting of: sucrose, polysorbate 20, polysorbate 80, cyclodextrin, dextrose, glycerol, polyethylene glycol, mannitol, sodium chloride, and an amino acid, wherein the formulation is a buffered aqueous solution having a pH of 4.5 to 7.6. The present invention also provides an immunoconjugate formulation that is substantially free of aggregates, the immunoconjugate formulation comprising: an immunoconjugate and one or more excipients selected from the group consisting of histidine, sucrose, glycine and sodium chloride, wherein the formulation is a buffered aqueous solution having a pH of 4.5 to 7.6. The present invention further provides an immunoconjugate formulation that is substantially free of both particles and aggregates.

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Patent Owner(s)

Patent OwnerAddress
IMMUNOGEN INC830 WINTER STREET WALTHAM MA 02451

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Amphlett, Godfrey Cambridge, US 13 356
Bartlett, Elizabeth Cambridge, US 5 139
Chih, Hung-wei Burlingame, US 12 175
Fleming, Michael S Londonderry, US 4 179
Zhang, Wei Philadelphia, US 2319 17796

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