Mouse having human leukemic stem cell and leukemic non-stem cell amplified therein, and method for production thereof

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United States of America Patent

PATENT NO 9125384
APP PUB NO 20110307964A1
SERIAL NO

12738559

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Abstract

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The invention relates to a method of selectively expanding human leukemic cells in a non-adult NOD/SCID/IL2rgnull mouse by transplanting a substance containing a leukemic stem cell derived from a human acute myelogenous leukemia patient to the mouse. In addition, the invention relates to screening for a medicament capable of eradicating leukemic stem cell (LSC), consideration of treatment methods suitable for individual patients, identification of a differentially expressed gene and the like, using a mouse with expanded human leukemic cells.

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Patent Owner(s)

  • THE JACKSON LABORATORY;RIKEN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ishikawa, Fumihiko Kanagawa, JP 24 360
Ohara, Osamu Kanagawa, JP 66 257
Saito, Yoriko Kanagawa, JP 9 53
Shultz, Leonard D Bar Harbor, US 20 52

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