Process for the preparation of statins in the presence of base

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United States of America Patent

PATENT NO 9126975
APP PUB NO 20130296561A1
SERIAL NO

13979976

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Abstract

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The present invention relates to a process for the preparation of statins by means of a Julia-Kocienski reaction between an aldehyde and a sulfone derivative in the presence of an alkaline metal alkoxy base. The resulting derivatives are suitable as building blocks for statin type compounds such as cerivastatin, fluvastatin, pitavastatin and rosuvastatin.

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Patent Owner(s)

Patent OwnerAddress
DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B V2613 AX DELFT

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bessembinder, Karin Henderika Maria Echt, NL 6 1
De, Lange Ben Echt, NL 28 8
Heemskerk, Dennis Echt, NL 14 6

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