Therapeutic compositions and methods for delivery of active agents cleavably linked to nanoparticles
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United States of America Patent
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Sep 22, 2015
Grant Date -
Jan 3, 2013
app pub date -
Dec 9, 2010
filing date -
Dec 9, 2009
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Abstract
Various embodiments of the present invention pertain to therapeutic compositions that comprise: (1) an active agent (e.g., paclitaxel); and (2) a nanoparticle (e.g., gold nanoparticle). In such embodiments, the active agent is covalently linked to the nanoparticle through a cleavable linker (e.g., a linker containing a hydrazone species). Other embodiments of the present invention pertain to methods of treating a condition in a subject by administering the above-described therapeutic compositions to the subject.
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