Process for producing oseltamivir phosphate and intermediate compound
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United States of America Patent
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Sep 22, 2015
Grant Date -
Nov 7, 2013
app pub date -
Jul 2, 2013
filing date -
May 30, 2008
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Abstract
Disclosed are a process suited to large scale synthesis with high yield for producing oseltamivir phosphate, in which a preparation of oseltamivir phosphate which is highly safe as a pharmaceutical product can be produced, and an intermediate compound for producing oseltamivir phosphate. In this production process, an intermediate compound represented by general formula (V) is synthesized by employing Michael reaction/Michael reaction/Horner-Wadsworth-Emmons reaction, and oseltamivir phosphate is produced by converting the substituent groups in this intermediate compound.
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