Methods for analysis of free and autoantibody-bound biomarkers and associated compositions, devices, and systems
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United States of America Patent
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Sep 22, 2015
Grant Date -
Jul 18, 2013
app pub date -
Nov 14, 2012
filing date -
Jan 18, 2012
priority date (Note) -
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Abstract
The present invention provides methods, compositions, and kits associated with analyzing, enriching, and/or isolating a biomarker or analyte in a biological sample. In one aspect, for example, a method for determining a concentration of a biomarker in a biological sample can include binding any unbound biomarker with an antibody specific for the biomarker to form antibody-bound biomarker, enriching the antibody-bound biomarker and any endogenous autoantibody-bound biomarker to form an enriched fraction, identifying the biomarker in the enriched fraction, and determining the concentration of the biomarker in the biological sample. In one aspect, the concentration of the biomarker is derived from initially unbound biomarker and autoantibody-bound biomarker in the biological sample.
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