Genetically modified human natural killer cell lines
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United States of America Patent
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Oct 6, 2015
Grant Date -
Apr 8, 2010
app pub date -
Sep 22, 2009
filing date -
Jul 10, 2004
priority date (Note) -
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Abstract
The invention provides a natural killer cell, NK-92, modified to express an Fc receptor on the surface of the cell, such as CD16 (FcγRIII-A), or other Fcγ or Fc receptors. The modified NK-92 cell can be further modified to concurrently express an associated accessory signaling protein, such as FcεRI-γ, TCR-ζ, or to concurrently express interleukin-2 (IL-2) or other cytokines. Additional methods are disclosed for various assays, assessments, and therapeutic treatments with the modified NK-92 cells.
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