Micro-reactor for observing particles in a fluid

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United States of America Patent

PATENT NO 9162211
APP PUB NO 20110097706A1
SERIAL NO

12912468

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Abstract

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A micro-reactor is provided for observing small particles, cells, bacteria, viruses or protein molecules in a fluid. The micro-reactor includes a first channel for containing the fluid and a second channel adjacent to the first channel. A gap connects the first channel and the second channel and a window transparent to the method of inspection is provided at the gap. A static or dynamic gradient, such as a gradient in concentration of a chemical or biological material, in pressure, in temperature, in electric potential, or in magnetic field, is applied across the gap, thereby causing the particles to cross the gap. By detecting a property of the particles upstream in the first channel and then applying a pressure burst over the channels when the property meets certain pre-set criteria, only selected particles can be placed in the gap.

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Patent Owner(s)

Patent OwnerAddress
FEI COMPANY5350 NE DAWSON CREEK DRIVE HILLSBORO OR 97124
STICHTING HET NEDERLANDS KANKER INSTITUUT1066 CX AMSTERDAM

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
De, Jong Alan Frank Eindhoven, NL 8 65
Dona, Pleun Veldhoven, NL 31 207
Peters, Jacobus Peter Johannes Amsterdam, NL 3 12
Van, Veen Gerard Anne Nicolaas Waalre, NL 2 6

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