Tumor antigens elicit anti-tumor humoral immune reactions in a subset of patients with polycythemia vera

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United States of America Patent

PATENT NO 9163088
APP PUB NO 20090304736A1
SERIAL NO

12446849

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Abstract

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The invention provides novel antigens, MPD5, PV13, and PV65, which belongs to the group of cryptic antigens without conventional genomic structure and is encoded by a cryptic open reading frame located in the 3′untranslated region (3′UTR) of myotrophin mRNA. The antigens elicit IgG antibody responses in a subset of PV patients, as well as patients with chronic myelogenous leukemia and prostate cancer. The translation of MPD5, PV13 and PV65 was mediated by a novel internal ribosome entry site (IRES) upstream of the open reading frame. Eliciting anti-tumor immune response against MPD5, PV13 and/or PV65 antigen in patients with myeloproliferative diseases is a novel immunotherapy.

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Patent Owner(s)

  • TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Yang, Xiao-Feng Huntingdon Valley, US 9 13

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