Methods and compositions for use in treatment of patients with autoantibody positive disease
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United States of America Patent
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Oct 27, 2015
Grant Date -
Jun 11, 2009
app pub date -
Jun 6, 2008
filing date -
Oct 13, 2005
priority date (Note) -
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Abstract
The present invention relates to methods and compositions for use in treatment of patients with autoantibody positive disease. In a specific embodiment, the present invention relates to a method of treating a patient that has an ANA titer of 1:80 or greater and/or greater than or equal to 30 IU/ml of anti-dsDNA antibodies in his/her blood plasma or serum comprising administering a therapeutically effective amount of an immunomodulatory agent, such as an antagonist of Neutrokine-alpha. Additionally provided is a method of reducing the frequency and/or quantity of corticosteroid administration to patients. In preferred embodiments, the patient has systemic lupus erythematosus. Methods for determining if a lupus patient is responding to medical treatment are also provided.
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