Polynucleotide mapping and sequencing
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United States of America Patent
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Nov 10, 2015
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app pub date -
Nov 18, 2009
filing date -
Nov 18, 2008
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Abstract
The present invention provides methods of obtaining structural information about a biopolymer sample. The methods include labeling portions of a biopolymer, such as DNA or RNA, linearizing the biopolymer in some cases, and determining the distance between the labels. The user can then compare different samples' between-label distances to qualitatively compare different samples and to assay a given sample for additions or deletions of nucleotides in the regions flanked by the labels. The methods also permit sequencing of biopolymers.
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