Reduction of the content of protein contaminants in compositions comprising a vitamin K-dependent protein of interest
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United States of America Patent
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Nov 17, 2015
Grant Date -
Aug 28, 2008
app pub date -
Dec 23, 2005
filing date -
Dec 23, 2004
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Abstract
The present invention relates to Vitamin K-dependent protein compositions having a very low, or negligible, content of protein contaminants. The present invention also relates to method applicable in the preparation of such Vitamin K-dependent protein compositions. Such methods may either be used alone or in sequential combination with the purpose of reducing the relative content of protein contaminants. The present invention is particularly relevant in the preparation of compositions of coagulation factors selected from Factor X polypeptides (FX/FXa), Factor IX polypeptides (FIX/FIXa), Factor VII polypeptides (FVII/FVIIa), and the anticoagulant Protein C, in particular Factor VII polypeptides.
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