Polynucleotides for multivalent RNA interference, compositions and methods of use thereof
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United States of America Patent
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Dec 1, 2015
Grant Date -
Jul 19, 2012
app pub date -
Jun 1, 2010
filing date -
Jun 1, 2009
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Abstract
The present invention includes bivalent or multivalent nucleic acid molecules or complexes of nucleic acid molecules having two or more target-specific regions, in which the target-specific regions are complementary to a single target gene at more than one distinct nucleotide site, and/or in which the target regions are complementary to more than one target gene or target sequence. Also included are compositions comprising such nucleic acid molecules and methods of using the same for multivalent RNA interference and the treatment of a variety of diseases and infections.
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