Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
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United States of America Patent
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Dec 15, 2015
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app pub date -
Jul 21, 2014
filing date -
May 1, 2009
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Abstract
Described herein are systems and methods for applying extremely low duty-cycle stimulation sufficient to treat chronic inflammation with progressively longer delays (off periods) from an initial stimulation. In particular, described herein are supra-threshold pulses of electrical stimulation sufficient to result in a long-lasting (e.g., >48 hours) inhibition of pro-inflammatory cytokines and/or effects of chronic inflammation; the delay between initial doses (which may be single-pulse doses) may be extended for subsequent doses, potentially dramatically enhancing battery and device longevity.
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