Prion protein as a receptor for amyloid-β oligomers
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United States of America Patent
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Dec 22, 2015
Grant Date -
Nov 18, 2010
app pub date -
Apr 28, 2008
filing date -
Apr 26, 2007
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Abstract
The invention provides methods of inhibiting suppression of long term potentiation, improving acute memory retention and spatial memory performance and treating Alzheimer's disease by administration of a PrPc antagonist or combinations thereof. Additionally, this invention provides pharmaceutical kits comprising, and methods for making and using, such combinations, as well as methods of identifying molecules that could function as PrPc antagonists.
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