Histone inhibition

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United States of America Patent

PATENT NO 9226939
APP PUB NO 20130338097A1
SERIAL NO

13990031

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention relates to a method of inhibiting the cytotoxic activity of extracellular histones in a subject, comprising administering an effective amount of a polyanion to the subject. In particular the invention relates to a method for the treatment of patients who are suffering from sepsis and employs polyanions to rapidly form complexes with and thus neutralize or inhibit the cytotoxic activity of extracellular histone proteins, for example, those found in the blood circulation of sepsis patients.

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Patent Owner(s)

Patent OwnerAddress
THE AUSTRALIAN NATIONAL UNIVERSITYACTON ACT 0200

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Freeman, Craig Geoffrey New South Wales, AU 11 73
Parish, Christopher Richard Campbell Australian Capital Territory, AU 22 240
Senden, Timothy John Aranda Australian Capital Territory, AU 9 23
Stephens, Ross Wentworth Stirling Australian Capital Territory, AU 8 13

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