Compositions and methods relating to non-human animals modified to promote production of selected gametes
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United States of America Patent
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Jan 19, 2016
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Nov 7, 2013
app pub date -
Jul 12, 2013
filing date -
Dec 27, 2010
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Abstract
Methods and compositions for producing selected non-human mammalian germ cells and gametes and for making non-human animals using the produced germ cells and gametes are provided by the present invention. Methods of generating a non-human embryo and/or animal derived from donor stem cells, methods of generating chimeric non-human animals having substantially all gametes and/or germ cells derived from the donor stem cells, methods of producing a non-human host embryo lacking functional endogenous germ cells and non-human host embryos incapable of developing endogenous gametes of the present invention are described herein.
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