Compositions and methods for inhibiting human host factors required for influenza virus replication
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United States of America Patent
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Jan 19, 2016
Grant Date -
Apr 11, 2013
app pub date -
Dec 10, 2010
filing date -
Dec 11, 2009
priority date (Note) -
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Abstract
This application relates to the modulation of host cell factors required for influenza virus replication. The application relates to compounds, including nucleic acid compounds (such as, e.g., small interfering RNAs (siRNAs)) and small molecules, that target human host cell factors involved in influenza virus replication, and the use of such compounds for modulating influenza virus replication and as antiviral agents. The application also relates to methods of treating an influenza virus infection and methods of treating or preventing a symptom or disease associated with influenza virus infection, comprising administering to a subject a composition comprising a compound, such as a nucleic acid compound (e.g., an siRNA) or small molecule, that targets a human host cell factor involved in influenza virus replication.
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