Multiparticulates
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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Feb 16, 2016
Grant Date -
Oct 23, 2008
app pub date -
Aug 31, 2005
filing date -
Aug 31, 2004
priority date (Note) -
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status (Latency Note)
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Abstract
Extrusion of a mix containing a pharmaceutically active agent can be achieved using a plasticizing excipient in an amount sufficient to act as plasticizer and also act as lubricant, thereby avoiding the need for inclusion of a lubricant. The invention provides multiparticulates with controlled release properties, substantially free of lubricant. The present invention is preferably directed to extruded multiparticulates containing an opioid such as oxycodone, an ammonium methacrylate copolymer such as Eudragit® RSPO, a plasticizing excipient such as preferably stearyl alcohol and a water permeability modifier such as preferably Eudragit® RLPO. The obtained multiparticulates show a release rate profile which is pH-independent.
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