Specific binding proteins and uses thereof
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United States of America Patent
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Feb 16, 2016
Grant Date -
Oct 10, 2013
app pub date -
Dec 11, 2012
filing date -
Dec 11, 2012
priority date (Note) -
Withdrawn
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Abstract
The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR. The binding members, particularly antibodies and fragments thereof, of the invention do not bind to EGFR on normal cells in the absence of amplification of the wild-type gene and are capable of binding the de2-7 EGFR at an epitope which is distinct from the junctional peptide. Antibodies of this type are exemplified by the novel antibody 806 whose VH and VL sequences are illustrated as SEQ ID NOs: 2 and 4 and chimeric antibodies thereof as exemplified by ch806.
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