Meganuclease variants cleaving a DNA target sequence from a glutamine synthetase gene and uses thereof

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United States of America Patent

PATENT NO 9273296
APP PUB NO 20110225664A1
SERIAL NO

13062795

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An I-CreI variant, wherein one of the two I-CreI monomers has at least two substitutions, one in each of the two functional subdomains of the LAGLIDADG core domain situated respectively from positions 28 to 40 and 44 to 77 of I-CreI, said variant being able to cleave a DNA target sequence from the glutamine synthetase gene. Use of said variant and derived products for improving expression system for the production of recombinant protein.

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Patent OwnerAddress
CELLECTIS8 RUE DE LA CROIX JARRY PARIS 75013

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Inventor Name Address # of filed Patents Total Citations
Smith, Julianne Le Plessis Robinson, FR 51 725

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