Methods and compositions for processes of rapid selection and production of nucleic acid aptamers
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United States of America Patent
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Mar 1, 2016
Grant Date -
Jan 1, 2009
app pub date -
Dec 27, 2007
filing date -
Dec 28, 2006
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Abstract
Embodiments herein relate to compositions and methods for making and using aptamers, for example, DNA aptamers (DCEs) and/or RNA aptamers. In some embodiments, methods relate to making and amplifying target DCEs. In certain embodiments, methods for making capture elements or aptamers concern using a reporter moiety and signal reducing moiety prior to amplifying a target-specific capture element. In some embodiments, methods disclosed herein may be used to rapidly generate large quantities of aptamers such as DCEs directed to a particular target agent. Some embodiments relate to systems for performing automated generation of aptamers.
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