Pharmaceutical combination for the treatment and/or chemosensibilization of refractory tumors to anticancer drugs

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United States of America Patent

PATENT NO 9278118
APP PUB NO 20150111832A1
SERIAL NO

14518242

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Abstract

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This invention is related to a pharmaceutical combination that contains a Casein kinase 2 (CK2) peptide inhibitor (termed P15) along with the standard chemotherapeutic drugs used in cancer treatment and which are administered together, separated or sequentially. The chemotherapeutic drugs include cisplatin, taxol, alkaloids from Vinca, 5-fluorouracil, doxorubicin, cyclophosphamide, etoposide, mitomycin C, imatinib, iressa, velcade (bortezomib), cytarabine (Ara C), fludarabine and mitroxantrone. The synergism between the P15 peptide and the anticancer drugs achieves an efficient concentration of each cytostatic drug in the combination which is from 10- to 100-fold lower than that for each cytostatic drug alone. The pharmaceutical combination described in this invention exhibits lower toxicity compared to that reported by the anticancer therapeutics and therefore, it represents a crucial advantage for its use in cancer therapy. Furthermore, the sequential administration of this pharmaceutical combination through the pretreatment with the P15 peptide leads to the chemo sensibilization of refractory tumors to the anticancer therapeutics.

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Patent OwnerAddress
BIOREC S ACERRITO 532 OFICINA 802 MONTEVIDEO C P 11 000

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Acevedo, Castro Boris Ernesto Ciudad De La Habana, CU 9 46
Alonso, Daniel Fernando Buenos Aires, AR 6 29
Besada, Pérez Vladimir Ciudad De La Habana, CU 2 4
Betancourt, Núñez Lázaro Hiram Ciudad De La Habana, CU 2 3
Castellanos, Serra Lila Rosa Ciudad De La Habana, CU 8 7
Fernández, de Cossio Dorta Duque Jorge Ciudad De La Habana, CU 2 4
Gil, Valdés Jeovanis Ciudad De La Habana, CU 6 29
Gomez, Daniel Eduardo Buenos Aires, AR 5 29
González, López Luis Javier Ciudad De La Habana, CU 11 18
Perea, Rodriguez Silvio Ernesto Ciudad De La Habana, CU 6 21
Perera, Negrin Yasser La Habana, CU 4 2
Ramos, Gómez Yassel Ciudad De La Habana, CU 2 4
Rodríguez, Ulloa Arielis La Habana, CU 2 4
Sánchez, Puente Aniel Ciudad De La Habana, CU 3 16

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